Explore the comprehensive collection of articles published in the Journal of Pharmacotherapy and Clinical Translational Research (JPCTR). Our archives provide access to all previous issues, featuring a wealth of knowledge in the fields of pharmacotherapy and clinical translational research.
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Volume 2
Issue 1 JANUARY- JUNE 2025
Volume 2 (Issue 1) JANUARY- JUNE 2025 Research Articles
AI-Powered Surveillance System for Enhancing Antiviral Treatment in Chronic Hepatitis C Patients
Vol.2(1); Pages:1-8. Published on April 2025
Abstract
The worldwide health problem of Chronic Hepatitis C (CHC) needs extended antiviral pharmacotherapy to properly treat the disease. SiMON-VC (Intelligent MONitoring System for antiviral pharmacotherapy in patients with chronic hepatitis C) serves as an innovative advanced AI-based system which optimizes treatment approaches specifically for antiviral drugs. SiMON-VC brings together patient monitoring systems with predictive analytics to apply machine learning algorithms thus improving healthcare decisions which leads to better treatment results with less adverse effects. Through its data collection and processing of patient data elements such as viral load dynamics and liver function tests and genetic markers and adherence patterns SiMON-VC generates adjusted treatment recommendations based on personal patient responses.SiMON-VC achieves predictions about treatment results through deep learning and reinforcement learning as part of its advanced artificial intelligence models to automatically modify treatment plans. Medical devices and electronic health records function together with wearable biosensors to provide persistent patient monitoring without interfering with patients. The system uses natural language processing (NLP) to review clinical notes for detecting drug interactions in addition to medication contraindications. The adaptable structure of SiMON-VC allows for dynamic risk assessment processes which helps medical staff prevent hepatotoxic effects and treatment non-response.Multiple clinical studies and practical healthcare settings have proven that SiMON-VC increases sustained virologic response rates alongside better patient treatment adherence. The system cuts down on patients’ need to visit hospitals frequently therefore reducing healthcare expenses yet delivering optimized therapy results. SiMON-VC functions as a groundbreaking tool which connects individualized medical care with clinical healthcare practices to transform infectious disease and hepatology management. The forthcoming improvements will include precise genomic medicine methods with blockchain-enhanced data protection mechanisms to enhance system capabilities.
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35 Years of Clinical Pharmacology Education at Comenius University: Evolution and Insights
Vol.2(1); Pages:9-14. Published on April 2025
Abstract
For the last thirty-five years the education program of clinical pharmacology at the Faculty of Pharmacy, Comenius University has undergone comprehensive changes to match medical science progress and pharmacotherapy development as well as healthcare requirements. This paper outlines the development of clinical pharmacology training which includes teaching strategies and fundamental research outcomes. The educational program has progressed through three major developments that include evidence-based medicine approaches alongside personalized pharmacotherapy training as well as advanced technological teaching solutions. Furthermore this paper examines how these technological changes affect both pharmacy practice delivery methods and patient care outcomes. Modern healthcare demands notification of permanent adjusting strategies in pharmacology education.
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Targeted Clinical Pharmacology and Rational Drug Prescribing Through the WHO 6-Step Approach
Vol.2(1); Pages:15-23. Published on April 2025
Abstract
For the last thirty-five years the education program of clinical pharmacology at the Faculty of Pharmacy, Comenius University has undergone comprehensive changes to match medical science progress and pharmacotherapy development as well as healthcare requirements. This paper outlines the development of clinical pharmacology training which includes teaching strategies and fundamental research outcomes. The educational program has progressed through three major developments that include evidence-based medicine approaches alongside personalized pharmacotherapy training as well as advanced technological teaching solutions. Furthermore this paper examines how these technological changes affect both pharmacy practice delivery methods and patient care outcomes. Modern healthcare demands notification of permanent adjusting strategies in pharmacology education.
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Overlooked Danger of ‘Triple Whammy’ Drug Interactions in Polish Community Pharmacies
Vol.2(1); Pages:24-31. Published on April 2025
Abstract
The coadministration of angiotensin-converting enzyme inhibitors (ACEIs) with diuretics and non-steroidal antiinflammatory drugs (NSAIDs) which comprises the “triple whammy” leads to a high danger of acute kidney injury (AKI). Healthcare professionals have yet to explore this condition extensively in regular community pharmacy care practice. This preliminary assessment investigates the rate and identification of the dangerous drug combination by pharmacists working at Polish pharmacies. The Triple Whammy drug combination presents multiple renal risks to patients yet remains frequently undetected as pharmacists need increased education for recognizing and intervening on these risks.
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Advancing Translation by Recognizing Evidence for Human-Centered Preclinical Approaches
Vol.2(1); Pages:32-38. Published on April 2025
Abstract
The mismatch between preclinical models and human outcomes presents challenges for translational research which hinders efficiency in drug development and biomedical advancements. This paper investigates translation improvement strategies through identification of reliable evidence which supports preclinical methods that closely mirror human condition. When preclinical research uses predictive validity testing with integrative methodologies and alternative models including organ-on-a-chip and computational simulations the research becomes more applicable to human use. The optimization of translational success requires a systematic model assessment method that combines biomarkers within improved experimental design approaches. When research takes human concerns as its top priority it can enhance both its performance and moral conduct as well as its real-world effects in medical uses.
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Volume 1
Issue 2 JULY – DECEMBER 2024
Research Articles Volume 1 (Issue 2) JULY – DECEMBER 2024
The Global Health Complex: Challenges and Opportunities in Interconnected World
Vol.1(2); Pages:1-6. Published on July 2024
Abstract
The global health complex encompasses a multifaceted array of challenges and opportunities shaped by interconnected systems, diverse socio-economic landscapes, and technological advancements. This complexity is characterized by the interplay of various determinants of health, including political, economic, social, environmental, and cultural factors, which influence health outcomes across different populations. One of the primary challenges lies in addressing health inequities and disparities that persist between and within countries, often exacerbated by global factors such as climate change, migration, and pandemics. Additionally, the rise of non-communicable diseases, antimicrobial resistance, and the need for sustainable healthcare systems present significant hurdles. However, these challenges also present opportunities for innovation in healthcare delivery, international collaboration, and policy-making. Technological advancements, such as telemedicine, big data analytics, and artificial intelligence, are revolutionizing healthcare practices, making them more accessible and efficient. Global health initiatives and partnerships, such as the Sustainable Development Goals (SDGs) and the World Health Organization’s (WHO) Global Health Agenda, play crucial roles in steering global efforts towards achieving universal health coverage and improving health outcomes worldwide. Addressing the global health complex requires a holistic and integrated approach, fostering resilience, equity, and sustainability in healthcare systems to ensure health and well-being for all.
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Travel Pharmacy: An Innovative Approach to Sustainability
Vol.1(2); Pages:7-14. Published on August 2024
Abstract
The travel health pharmacy sector is rapidly evolving to address the increasing demand for comprehensive healthcare services for international travelers. This new model emphasizes sustainability, integrating environmental, economic, and social dimensions to ensure long-term viability and positive impacts on global health. By adopting eco-friendly practices, leveraging technology, and promoting preventive care, travel health pharmacies can minimize their ecological footprint while enhancing patient outcomes. This model encourages the use of digital health tools for remote consultations, the distribution of environmentally friendly medical supplies, and the implementation of sustainable business practices. Additionally, it underscores the importance of collaboration with global health organizations and local communities to address health disparities and promote wellness. Through these strategies, travel health pharmacies can play a pivotal role in fostering a healthier, more sustainable future for global travelers and the planet.
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Consumer Perspective on Adverse Drug Reactions: Understanding Risks and Implications for Patient Safety
Vol.1(2); Pages:15-23. Published on September 2024
Abstract
The consumer perspective on adverse drug reactions (ADRs) is a critical element in the safe use of medications and the overall management of patient care. ADRs encompass any unintended or harmful effects that arise from the use of pharmaceuticals, ranging from mild symptoms to severe complications. For consumers, understanding these risks is vital for making informed decisions about their health and treatment plans. This paper explores how consumers perceive ADRs, the factors influencing their understanding and reporting of these reactions, and the implications for patient safety. It highlights the role of healthcare professionals in educating patients, the impact of social media and misinformation, and the importance of robust reporting systems. By enhancing public awareness, fostering open communication between patients and healthcare providers, and implementing effective risk communication strategies, consumers can better navigate the complexities of medication use and mitigate the risks associated with ADRs. This paper underscores the need for a collaborative approach to managing ADRs, emphasizing the importance of patient empowerment and informed consent in the safe use of pharmaceuticals.
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Implementing Dried Blood Spot Sampling for Clinical Pharmacokinetic Determinations: Considerations from the IQ Consortium Microsampling Working Group
Vol.1(2); Pages:24-32. Published on September 2024
Abstract
Dried Blood Spot (DBS) sampling has emerged as a promising method for clinical pharmacokinetic determinations, offering several advantages over traditional blood sampling techniques, such as reduced blood volume, ease of transport, and patient comfort. The IQ Consortium’s Microsampling Working Group provides a comprehensive overview of the considerations involved in implementing DBS sampling for clinical pharmacokinetics. This method involves collecting a small volume of blood (typically 20-50 µL) on filter paper, allowing for simple and stable storage at room temperature. The IQ Consortium’s guidelines address key factors such as sample collection, handling, storage, and analysis to ensure accuracy, precision, and reliability of pharmacokinetic data derived from DBS samples. These considerations are critical for clinical studies, especially in pediatric populations and populations with restricted blood volume, where traditional sampling methods may be impractical or unfeasible. The IQ Consortium highlights the need for validation of DBS assays, the influence of hematocrit, and the impact of pre-analytical variables on the integrity of DBS samples. Furthermore, it provides recommendations for study design, including the choice of DBS collection devices, the impact of the timing of sampling, and the handling of samples from different populations.
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Phytoplankton Carotenoid Pigments: A Promising Pathway for Cancer Therapy
Vol.1(2); Pages:33-42. Published on October 2024
Abstract
Phytoplankton carotenoid pigments, naturally occurring bioactive compounds with diverse biochemical properties, have garnered significant attention as potential agents in cancer therapy. These pigments, including fucoxanthin, astaxanthin, and beta-carotene, exhibit potent antioxidant, anti-inflammatory, and antitumor activities, making them promising candidates for integrative oncology approaches. This paper explores the multifaceted roles of phytoplankton-derived carotenoids in cancer prevention and treatment. Key mechanisms of action include the induction of apoptosis in cancer cells, inhibition of angiogenesis and metastasis, and protection against oxidative stress-induced cellular damage. Advances in extraction and synthesis methods have enhanced the availability and stability of these pigments, paving the way for clinical applications.Despite their therapeutic potential, challenges such as optimal delivery systems, dosage standardization, and large-scale sustainable production must be addressed. This paper also discusses preclinical and emerging clinical evidence supporting the efficacy of carotenoids in targeting specific cancer types, including colorectal, breast, and prostate cancers. Furthermore, the integration of carotenoids with conventional therapies, such as chemotherapy and radiotherapy, is examined, highlighting synergistic effects that may improve treatment outcomes. Future research should focus on translational studies to overcome current limitations, along with an exploration of personalized medicine approaches that incorporate carotenoid-based interventions. This review underscores the potential of phytoplankton carotenoid pigments as innovative and sustainable tools in the fight against cancer, aligning with the growing demand for natural and less invasive therapeutic options.
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Issue 1 JANUARY – JUNE 2024
Research Articles Volume 1 (Issue 1) JANUARY – JUNE 2024
Implementing Population Health in Pharmacy Education: Insights from a Developing Country
Vol.1(1); Pages:1-8. Published on April 2024
Abstract
Implementing population health principles into pharmacy education presents a transformative opportunity for developing countries. This paper explores the implications of integrating a needs-based pharmacy education framework aligned with population health goals. Drawing on insights from developing countries, the discussion highlights challenges, strategies, and potential outcomes of this approach. Key considerations include curriculum adaptation, stakeholder engagement, and the role of pharmacists in public health. Ultimately, this perspective underscores the importance of preparing pharmacists to address community health needs effectively.
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Pharmacist Roles Reimagined: Embracing Planetary Health Perspectives
Vol.1(1); Pages:9-17. Published on May 2024
Abstract
In response to global environmental challenges, the role of pharmacists is undergoing a transformative shift towards embracing planetary health perspectives. This abstract explores how pharmacists, traditionally focused on patient care and medication management, are increasingly recognized for their potential to contribute to sustainable healthcare practices and environmental stewardship. Integrating planetary health principles into pharmacy education, practice, and policy is essential for addressing the interconnected issues of climate change, biodiversity loss, and public health. This paper examines innovative approaches that pharmacists can adopt to promote environmental sustainability, such as advocating for eco-friendly medication packaging, supporting green pharmacy initiatives, and participating in community health programs that emphasize ecological balance. Challenges include navigating regulatory frameworks, enhancing interdisciplinary collaboration, and fostering awareness among healthcare professionals and the public about the intersection of health and the environment. Ultimately, pharmacists play a vital role in advancing planetary health agendas, contributing to global efforts towards a healthier, more sustainable future.
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Pharmacoeconomic Analysis of Pharmacist-Led Interventions
Vol.1(1); Pages:18-25. Published on May 2024
Abstract
Pharmacoeconomic analysis plays a crucial role in evaluating the cost-effectiveness of healthcare interventions, including those led by pharmacists. This study examines the economic impact of pharmacist-led interventions through a comprehensive pharmacoeconomic framework. It reviews cost-benefit, cost-effectiveness, and cost-utility analyses to assess the financial implications of such interventions across different healthcare settings. The findings highlight how pharmacist-led initiatives contribute to healthcare cost savings, improved patient outcomes, and enhanced medication adherence. Moreover, this analysis considers the methodological challenges and opportunities in conducting pharmacoeconomic evaluations of pharmacist-led interventions, emphasizing the importance of integrating economic perspectives into clinical practice guidelines and healthcare policy decisions.
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Recent Strategic Advances in Medicinal Chemistry: Innovations in Targeted Drug Design, Synthetic Methodologies, and Personalized Medicine
Vol.1(1); Pages:26-35. Published on June 2024
Abstract
Medicinal chemistry has witnessed significant strategic advancements in recent years, particularly in the domains of targeted drug design, synthetic methodologies, and personalized medicine. These advancements have revolutionized the way drugs are discovered, developed, and tailored to individual patient needs. Innovations in targeted drug design have enabled the creation of more effective and selective therapeutic agents, minimizing offtarget effects and enhancing clinical outcomes. Novel synthetic methodologies have streamlined the production of complex molecules, reducing time and cost associated with drug development. Personalized medicine, driven by advances in genomics and biotechnology, has paved the way for treatments tailored to the genetic profile of patients, improving efficacy and safety. This review explores these cutting-edge developments, highlighting key breakthroughs and their implications for the future of medicinal chemistry.
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The Evolving Role and Impact of Clinical Pharmacy Services in Mental Health Care Across Europe
Vol.1(1); Pages:36-43. Published on June 2024
Abstract
The integration of clinical pharmacy services into mental health care across Europe has seen significant evolution over recent years. This commentary explores the expanding roles and impact of clinical pharmacists within the mental health care system, highlighting their contributions to patient outcomes, medication management, and multidisciplinary care. Clinical pharmacists are increasingly recognized for their expertise in psychopharmacology, providing critical support in medication optimization, adherence, and side effect management. Their involvement in patient education, individualized care plans, and collaborative practice with psychiatrists and other healthcare providers enhances the overall quality of mental health care. The paper examines various models of clinical pharmacy services in mental health settings, identifies best practices, and discusses the challenges and opportunities associated with integrating these services across different European healthcare systems. By addressing the unique needs of mental health patients and contributing to more effective and safer use of medications, clinical pharmacists play a pivotal role in improving mental health outcomes. This commentary underscores the need for continued advocacy, education, and research to further advance the role of clinical pharmacy services in mental health care.
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