Welcome to the Current Issues section of the Journal of Emerging Drug Formulation Technologies (JEDFT). Here, you will find the latest research articles, reviews, case studies, and technical notes published in the most recent issue of our journal. We are dedicated to advancing the field of pharmaceutical sciences by sharing cutting-edge research focused on innovative drug formulation technologies.
Featured Articles in the Latest Issue
- Volume 2(Issue 2) JULY – DECEMBER 2025
Research Articles
Electrospinning of Loratadine: Development and Characterization of Fast dissolving Oral Thin Film about Loratadine
Vol.2(2); Pages:1-8. Published on July 2025
Abstract
The oral thin films (OTFs) with fast-dissolving properties are becoming an efficient method of drug delivery, especially among the patients who have difficulty or prefer not to use the traditional pharmaceutical forms of drug delivery. This paper examines the design and profile of a loratadine incorporated electrospun oral thin film in a bid to develop rapid systemic delivery. The OTF synthesis process involved the utilization of PEG-400 as a plasticizer and used polyvinyl alcohol (PVA) as a film-forming polymer. Some essential characterisation parameters such as the thickness, disintegration time, drug content, tensile strength and in vitro dissolution were tested. The optimized formula showed great disintegration in 18 seconds and 92.4 percent of loratadine was disintegrated in three minutes. Scanning electron microscopy (SEM) showed that nanofibers were equitably distributed in the OTF. Such findings emphasize the success of the electrospinning technique in producing high-performing OTFs to release drugs quickly, and has a potential commercial-scale application of loratadine and other drugs.
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Design and Evaluation of Thermosensitive Nasal Gel of Rizatriptan for Enhanced Brain Targeting in Migraine
Vol.2(2); Pages:9-16. Published on July 2025
Abstract
The nasal administration of drugs directly to the brain region provides a noninvasive option of managing acute neurological disorders like migraine. This research project was to prepare a thermoresponsive in situ nasal gel loaded with rizatriptan benzoate to meet the need of fast focused migraine relief. The poloxamer 407 and hydroxypropyl methylcellulose (HPMC) were also optimized to get a sol-gel change at nasal temperature (32- 34 o C) so that the gel would be in liquid state since it would be easy to administer and would gel on reaching the nasal mucosa to ensure sustained release. In vitro diffusion analysis revealed that the drug was released continuously within a 4-hour period, and it provides a long-term treatment approach. Comparative in vivo pharmacokinetic analysis in Wistar rats showed an augmented brain bioavailability of 1.8-fold than the oral solution of the drug, with a significantly higher Tmax (p < 0.05) which meant that the drug was rapidly taken up in the brain. There was no irritation of the nasal mucosa, and the formulation was well received. These findings present the opportunity of a novel uptake in this nasal gel formulation as a promising novelty to fastacting and brain-bound migraine treatment.
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Optimization of Lipid-Polymer Nanoparticles for Oral Curcumin Delivery: An In Silico Approach
Vol.2(2); Pages:17-24. Published on August 2025
Abstract
Curcumin is a bioactive phytochemical isolated in Curcuma longa with beneficial therapeutic effects whose clinical application is limited because of poor aqueous solubility and lack of oral bioavailability. The objective of this research is to produce lipid-polymer hybrid nanoparticle (LPHNPs) as a new platform of drug delivery, through which curcumin can be improved in terms of solubility and bioavailability. The critical formulation parameters that were optimized using a BoxBehnken design were lipid:polymer ratio and surfactant concentration. The obtained nanoparticles had an average size of 124.7nm, the encapsulation efficiency of 89.2 percent, and extended drug release in 24 hours providing extended therapeutic effect. Pharmacokinetics studies carried out in rats ligature studies also showed that there was a 4.6-fold gain in AUC (area under the curve) relative to plain curcumin suspension verifying the increased oral bioavailability of curcumin as delivered through LPHNPs. The investigation establishes that LPHNPs could be effective and promising in oral administration of poorly soluble natural products such as curcumin, and provides possible solution to increase clinical efficacy of phytopharmaceuticals.
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Take home 3D-Printed Buccal Tablet of Controlled Release of Metoprolol 3D-Printed Personalized Dosage Strategy
Vol.2(2); Pages:25-33. Published on August 2025
Abstract
The use of three-dimensional (3D) printing technology has transformed pharmaceutical formulations and the 3D printers allow the segment-wise customization of drug delivery systems based on the specific needs of the patients. This paper presents the work on designing of a 3D-printed buccal tablet that can be used to release a dose of metoprolol tartrate, which is an everyday used antihypertensive drug. The buccal tablet matrix was prepared on the basis of hydroxypropyl cellulose (HPC) and polyvinyl alcohol (PVA) being the main polymers chosen due to mucoadhesive activity and its capability to regulate drug release. The tablet was made using the fused deposition modeling (FDM) technology, which enabled the exactness of the layered structure and altering the geometry in order to improve buccal adhesion and drug release. The drug release profile was also found to be sustainable, up to 8 hours, and hence delivery of drug, through in vitro examination, was maintained in consistency, as well as strong mucoadhesion with the buccal mucosa. In vivo experimentations were done on rabbit models which revealed that the buccal tablet afforded the same bioavailability level as the traditional oral tablet but with longer Tmax and lower Cmax data, that represented slower manipulation into the bloodstream. These observations indicate that the 3D-printed buccal tablets hold a potential as an alternative method of treatment of cardiovascular diseases, specifically hypertension, since 3D-printed buccal tablets have a sustained effect, fewer dosages are needed, and there is an increase in patient adherence.
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Design and Testing of a Microemulsion Gel Transdermal Delivery System of Ibuprofen: Skin Permeation
Vol.2(2); Pages:34-42. Published on September 2025
Abstract
Transdermal system has non-invasive method of drug delivery that has a lasting therapeutic effects and minimises a gastrointestinal side effects. This study was intended to design and test a microemulsion based gel containing ibuprofen as an agent to increase skin permeation and enrich the onset of action. Microemulsion formulation comprised 10% isopropyl myristate, 5% Tween 80, 5% ethanol and water populated in Carbopol 934 gel-base for increased viscosity and stability. The physicochemical characteristic of the gel was obtained, showing high (96.3%) drug-loading efficiency and appropriate viscosities that make it suitable to be used topically. Ex vivo skin permeation study in Franz diffusion cells indicated the highest 3.1-fold difference in the flux of the ibuprofen over conventional gel systems. In vivo studies on rats showed that the gel has a quick onset of effect and its ability to demonstrate a higher percentage of decrease in paw edema demonstrates that it is effective in its anti-inflammatory behavior. The microemulsion gel was a highly potential alternative that would be of excellent use in rapid action and effective administration of NSAIDs, in pain medication and antiinflammatory treatment.
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