The Journal of Emerging Drug Formulation Technologies (JEDFT) maintains a comprehensive archive of all published issues, providing a valuable resource for researchers, academics, and practitioners in the field of pharmaceutical sciences. The archive is organized by year and volume, allowing easy access to past research contributions.
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Volume 2
Issue 1 JANUARY- JUNE 2025
Volume 2(Issue 1) JANUARY- JUNE 2025 Research Articles
Phytosome: An Innovative Method to Increase the Bioavailability and Effectiveness of Herbal Drugs
Vol.2(1); Pages:1-8. Published on April 2025
Abstract
The long history of human use for herbal medicines stems from both therapeutic advantages and weak side effects. The clinical benefits of herbal medicines remain limited by three factors: poor bioavailability, low solubility as well as chemical instability. Phytosome technology serves as an innovative delivery method which solves absorption and bioavailability problems by improving the uptake of herbal compounds. The phospholipid composition of Phytosomes makes them able to combine with phytoconstituents which enhances their membrane permeability properties. Phytosomes prove more effective than standard herbal extracts because their pharmacokinetic characteristics increase extract solubility as well as biological membrane permeability and reach better systemic distribution. Several scientific studies demonstrate that phytosomes increase the therapeutic properties of bioactive compounds including curcumin, quercetin, silymarin, and ginkgo flavonoids. The extended applications that benefit from phytosomes include pharmaceutical formulations as well as cosmetic and nutraceutical applications. This paper explains how phytosomes form and operates while analyzing their superior features compared to traditional herbal delivery methods with recent developments in this area. Herbal medicine can experience revolutionary changes thanks to phytosome integration because this method improves both therapeutic impact and clinical success of natural drug formulations.
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New AI Technologies in the Development of Solid Dosage Forms
Vol.2(1); Pages:9-16. Published on April 2025
Abstract
Solid drug formulations such as tablets and capsules experience a fundamental transformation because physicians now apply Artificial Intelligence (AI) technology during their development process. Pharmaceutical companies use artificial intelligence technologies especially ML and DL together with neural networks and computational modeling for transforming drug formulation and manufacturing operations and quality control management. The predictive models AI generates decrease typical formulation development timelines while cutting down operational costs by suggesting excipients and APIs for selection. The integration of predictive modeling systems with PAT technologies and chemometric models and digital twin simulations allows continuous critical quality attribute oversight for maintaining product uniformity and regulatory compliance. Pharmaceutical scientists use Generative AI and natural language processing to search for data when they perform a patent review with literature analysis for new formulation strategies development.Manufacturers streamline tablet compression and coating and granulation process control through AI-based robotic automation and real-time image processing for improved product quality and lower deviation occurrences. Pharmaceutical businesses use AI-based QbD systems to develop continuous product processes that meet regulatory criteria. Artificial Intelligence technology allows healthcare providers to make personalized medication products at exact dosage levels despite facing challenges such as security concerns and regulatory confirmation and technical complexities of AI systems during implementation. Proper management of existing challenges stands as essential for artificial intelligence to reach its maximum potential in pharmaceutical solid dosage form development. Future pharmaceutical research will progress through technology combinations of AI with big data analytics together with cloud computing and blockchain for quicker and less expensive patient-oriented drug development.
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Combining 6G networks with AI-powered IoT to create next-generation smart healthcare systems
Vol.2(1); Pages:17-24. Published on April 2025
Abstract
Fast-developing technologies such as Artificial Intelligence (AI) and the Internet of Things (IoT) along with 6G networks as well as blockchain and edge computing systems are transforming medical care through the creation of digitally connected healthcare environments. Smart healthcare utilizes modern technologies to boost clinical oversight of patients and to develop better diagnostic approaches as well as exact treatment methods and immediate clinical choices. AI algorithms and deep learning frameworks help detect diseases early before they spread and conduct predictive analysis functions. Similarly IoT-enabled medical products monitor patients remotely and track their health status constantly. The 6G networks deliver fast data exchange and instant processing combined with reliable communication protocols which establish smooth connectivity between medical tools and wearable monitors together with cloud infrastructure. The decentralized ledger systems on Blockchain technology provide strong security to protect health records alongside complete data privacy. Edge computing enhances medical realtime responsiveness through near-source processing of medical data which results in reduced latency. Modern robotics together with automation enhance both therapeutic processes and surgical accuracy as well as robotic systems that support elderly care needs. Such technology amalgamation builds an intelligent healthcare system which provides medical excellence at lower costs and better serves patients especially in remote regions. The research analyzes the current uses and advantages of new technologies together with advanced networks in smart healthcare platforms while examining upcoming trends and obstacles in this field. It highlights how innovative technologies modify healthcare delivery systems of today.
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Enhancing Remote Patient Care with AI and Machine Learning: A Revolution in Tele-Pharmacy
Vol.2(1); Pages:25-33. Published on April 2025
Abstract
National tele-pharmacy systems are benefiting from Artificial Intelligence (AI) and Machine Learning (ML) features which create better remote patient care possibilities through efficient services and precise drug management. Medical solutions powered by AI technologies are transforming the drug management process and clinical discussions between physicians and patients as well as pharmaceutical distribution channels. The combination of AI-based chatbots with virtual assistants delivers immediate medication advice to customers who maintain their drug intake and reduce their mistakes through the analysis of patient data achieved by ML algorithms for designing targeted treatment plans. Remote health monitoring systems that utilize AI technology allow pharmacists to perform proactive actions in medication therapy management through continuous patient health tracking. After implementing AI-driven decision support systems into drug dispensing operations together with supply chain optimization the operational efficiency of these systems enhances. The implementation of AI in tele-pharmacy requires resolving privacy issues and regulatory compliance doubts and ethical concerns in order to achieve optimal results. The current situation, present innovations and projected developments of AI in telepharmacy are analyzed to demonstrate its power as a tool for distant pharmaceutical treatment and better patient health results.
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Pharmacokinetics Advances: Up-and-Coming Scholars Influencing Drug Transport and Metabolism
Vol.2(1); Pages:34-40. Published on April 2025
Abstract
Drug metabolism and transport investigations form an essential foundation of pharmacology because they determine both drug effectiveness together with medication security and individual treatment approaches. This editorial showcases revolutionary research achievements from potential star scientists active in Drug Metabolism and Transport areas for Frontiers in Pharmacology during 2022. The research investigates both new metabolic routes and drug-to-drug reaction patterns together with transport system mechanisms which affect pharmaceutical development for precision healthcare. The collection demonstrates the next-generation methods for pharmacokinetic and pharmacodynamic research using both computational modeling and advanced in vitro and in vivo testing approaches. The editorial explains how regulatory approaches combine with translation difficulties for perfecting medication delivery systems and treatment methods. The technical advancement of treatments depends on continuing support for new talents which delivers improved drugs to differing patient groups while reducing their negative effects.
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Volume 1
Issue 2 JULY – DECEMBER 2024
Research Articles Volume 1 (Issue 2) JULY – dECEMBER 2024
Pharmacoeconomics Preparedness among Final Year Pharmacy Students in South Africa
Vol.1(2); Pages:1-8. Published on August 2024
Abstract
Pharmacoeconomics is an essential component of healthcare decision-making, offering critical insights into the cost-effectiveness and value of pharmaceutical interventions. This study investigates the perceptions and preparedness for the application of pharmacoeconomics among final-year Bachelor of Pharmacy students in South Africa. Using a national cross-sectional survey design, we gathered data from students across multiple universities to assess their understanding, confidence, and readiness to apply pharmacoeconomic principles in their future practice.The survey included questions on demographic information, educational background, exposure to pharmacoeconomics coursework, and self-assessed preparedness. Additionally, we evaluated their perceptions of the importance of pharmacoeconomics in practice and their confidence in performing pharmacoeconomic analyses. The findings revealed that while students generally recognized the importance of pharmacoeconomics, there were significant gaps in their preparedness and confidence levels. Most students reported limited exposure to practical applications and real-world scenarios, which contributed to their perceived lack of readiness.Furthermore, the study identified variations in the quality and extent of pharmacoeconomics education among different institutions. Recommendations for curriculum enhancements include increased emphasis on hands-on training, integration of real-world case studies, and interdisciplinary collaboration to bridge the gap between theoretical knowledge and practical application. By addressing these educational gaps, pharmacy programs can better prepare graduates to contribute effectively to healthcare decision-making processes, ensuring the optimal use of resources and improved patient outcomes.
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Pharmacy Students’ Attitudes Towards Patient Safety: A Cross-Sectional Study Across Six Developing Countries
Vol.1(2); Pages:9-18. Published on September 2024
Abstract
Patient safety is a critical component of healthcare, and pharmacists play a crucial role in ensuring safe medication practices. This study aims to evaluate the attitudes of pharmacy students towards patient safety across six developing countries, providing a comprehensive understanding of the educational and cultural factors influencing these attitudes. A cross-sectional survey was conducted involving pharmacy students from universities in Ghana, Nigeria, Pakistan, India, Brazil, and Egypt. The survey included the Patient Safety Attitudes Questionnaire (PSAQ), which assesses various dimensions of patient safety, such as teamwork, communication, error reporting, and systemsbased practices. Results showed significant variations in attitudes towards patient safety among students from different countries, highlighting the influence of local educational systems, healthcare practices, and cultural norms. Students generally recognized the importance of patient safety but displayed varying levels of confidence in their ability to contribute to safety practices. Notably, students from countries with more developed healthcare infrastructure and patient safety curricula exhibited more positive attitudes. The study identified key areas for improvement in pharmacy education, including the need for enhanced training in patient safety, more robust curricula integrating safety principles, and increased opportunities for practical experience. Furthermore, the findings underscore the importance of fostering a culture of safety within healthcare institutions and the role of interprofessional education in promoting collaborative practices.
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Advancing Neuroscience Drug Discovery Through Quantitative Systems Pharmacology: Current Landscape and Future Challenges
Vol.1(2); Pages:19-27. Published on September 2024
Abstract
Quantitative Systems Pharmacology (QSP) has emerged as a transformative approach in neuroscience drug discovery and development, bridging the gap between experimental biology, pharmacology, and computational modeling. Neuroscience, a domain characterized by its complexity, benefits significantly from QSP’s ability to integrate multiscale data, enabling the prediction of drug efficacy, safety, and mechanisms of action. This methodology provides an innovative framework to address critical challenges in understanding brain disorders, including Alzheimer’s disease, Parkinson’s disease, and psychiatric conditions.The application of QSP in neuroscience drug development facilitates better target validation, optimization of dosing strategies, and identification of biomarkers for clinical response. By leveraging mechanistic models, researchers can explore disease pathways, simulate therapeutic interventions, and reduce the high attrition rates associated with central nervous system (CNS) drug development. Additionally, QSP offers significant opportunities to refine precision medicine approaches by tailoring interventions based on individual patient variability in disease biology and drug response.Despite its promise, the field faces challenges such as integrating diverse datasets, ensuring model validity, and navigating the inherent heterogeneity of CNS disorders. Addressing these issues requires interdisciplinary collaboration, advances in computational capabilities, and robust experimental validation. This abstract explores the current status, opportunities, and challenges associated with the adoption of QSP in neuroscience, emphasizing its potential to revolutionize CNS drug discovery and improve patient outcomes.
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Evaluating the Long-Term Impact and Sustainability of a Decade-Long Community Pharmacy Disease Management Service
Vol.1(2); Pages:28-36. Published on October 2024
Abstract
Community pharmacies have evolved into vital healthcare access points, expanding their roles to include disease management services. This study evaluates a 10-year disease management program implemented in community pharmacies, focusing on its impact, sustainability, and scalability. The service targeted chronic conditions such as diabetes, hypertension, and dyslipidemia, emphasizing medication adherence, lifestyle modifications, and routine monitoring. The evaluation utilized a mixed-methods approach, incorporating quantitative metrics such as clinical outcomes, healthcare utilization, cost-effectiveness, and patient satisfaction, alongside qualitative insights from pharmacists and patients.Findings reveal a significant improvement in patient health outcomes, including reductions in HbA1c levels, blood pressure control rates, and lipid profiles. Patient satisfaction scores consistently surpassed 90%, indicating high acceptance. Economically, the program demonstrated cost-effectiveness by reducing hospital admissions and emergency visits related to poorly managed chronic conditions. However, challenges such as pharmacist workload, program funding, and integration with broader healthcare systems posed threats to long-term sustainability.The study highlights key enablers for success, including robust pharmacist training, interdisciplinary collaboration, and technology integration for monitoring and communication. Recommendations for scalability include policy support, reimbursement structures, and enhanced public-private partnerships. This research underscores the transformative potential of community pharmacy-based disease management services in enhancing population health and reducing healthcare costs.
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Optimizing Compounding Quality: Chenodeoxycholic Acid Capsules for Dutch Cerebrotendinous Xanthomatosis Patients
Vol.1(2); Pages:37-46. Published on October 2024
Abstract
Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive lipid storage disorder caused by mutations in the CYP27A1 gene, leading to the accumulation of cholestanol and bile acid precursors. Chenodeoxycholic acid (CDCA) is a critical therapy for CTX, effectively reducing cholestanol levels and preventing disease progression. However, the availability and quality of CDCA formulations vary, particularly in compounded preparations. This study focuses on the development and quality evaluation of pharmacy-compounded CDCA capsules tailored for Dutch CTX patients.The research outlines the compounding process, including raw material selection, formulation optimization, and quality control assessments such as uniformity of content, dissolution rate, and stability testing. Advanced analytical methods, including high-performance liquid chromatography (HPLC), were employed to ensure precise dosing and identify degradation products. Additionally, patient-centered considerations, such as capsule size and excipient compatibility, were addressed to enhance adherence and therapeutic outcomes. Results demonstrated that compounded CDCA capsules met regulatory quality standards, offering a reliable alternative to commercially unavailable formulations. The study underscores the importance of rigorous compounding practices and quality assurance in delivering safe and effective treatments for rare diseases. These findings contribute to the broader understanding of personalized pharmaceutical care for niche patient populations.
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Issue 1 JANUARY – JUNE 2024
Research Articles Volume 1 (Issue 1) JANUARY – JUNE 2024
Exploring Pharmacy’s Integral Role in the Global Movement of Travel Medicine
Vol.1(1); Pages:1-8. Published on April 2024
Abstract
Pharmacy’s role in travel medicine is pivotal as global travel continues to expand, presenting unique health challenges and opportunities. Pharmacists are increasingly recognized for their essential contributions to promoting safe and healthy travel experiences. This paper examines pharmacy’s integral role in the global movement of travel medicine, emphasizing their involvement in pre-travel health consultations, administering vaccinations, managing travel-related medications, and providing education on health risks and preventive measures. By bridging the gap between healthcare and travelers, pharmacists play a critical part in safeguarding public health on a global scale.
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Incorporating Pharmacometrics into Pharmacoeconomic Models: Applications in Drug Development
Vol.1(1); Pages:9-17. Published on April 2024
Abstract
Pharmacoeconomic modeling plays a crucial role in evaluating the economic outcomes of pharmaceutical interventions. Integrating pharmacometrics into these models enhances their predictive accuracy by incorporating quantitative drug exposure-response relationships. This synergy enables more precise estimations of clinical outcomes and cost-effectiveness, thereby supporting informed decision-making in drug development and healthcare policy. This paper explores the theoretical framework and practical applications of incorporating pharmacometrics into pharmacoeconomic models, highlighting its potential to optimize resource allocation and improve patient outcomes in pharmaceutical research and development.
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Patient Safety: A Paramount Concern for Caregivers
Vol.1(1); Pages:18-26. Published on May 2024
Abstract
Patient safety remains a paramount concern for caregivers across all healthcare settings, driven by the imperative to prevent harm and ensure optimal health outcomes. This focus encompasses a broad spectrum of activities, from medication management and surgical safety to infection control and the implementation of technology in healthcare. Central to the discourse on patient safety is the need for a culture of transparency and continuous improvement, where healthcare professionals are encouraged to report errors and near misses without fear of retribution. This culture supports the identification of system flaws and the development of robust strategies to mitigate risks. Furthermore, the integration of evidence-based practices, ongoing education, and interprofessional collaboration are critical components in enhancing patient safety. Technological advancements, such as electronic health records and automated dispensing systems, also play a significant role in reducing errors and improving patient outcomes. However, challenges persist, including resource limitations, varying levels of safety awareness among staff, and the complexity of modern healthcare environments. Addressing these challenges requires a concerted effort from all stakeholders, including policymakers, healthcare administrators, and frontline caregivers. Through a multifaceted approach that prioritizes patient safety at every level of care, it is possible to significantly reduce adverse events and improve the overall quality of healthcare.
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Promoting Global Health Care: Strategies and Ethics in Pharmaceutical Industry Practices
Vol.1(1); Pages:27-34. Published on May 2024
Abstract
Promoting global health care presents both opportunities and challenges for the pharmaceutical industry. This paper examines the strategies employed by Big Pharma to enhance global health outcomes, focusing on ethical considerations and their impact. Key areas explored include access to medicines, research and development priorities, pricing strategies, regulatory compliance, and corporate social responsibility initiatives. The analysis underscores the complex interplay between profit motives and public health imperatives, highlighting the importance of ethical frameworks in guiding industry practices.
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Pharmacoeconomics Framework in Cyprus: Opportunities and Implementation Strategies
Vol.1(1); Pages:35-43. Published on June 2024
Abstract
The implementation of a pharmacoeconomics framework in Cyprus presents a transformative opportunity for optimizing healthcare resource allocation and enhancing patient outcomes. Pharmacoeconomics, as a discipline, evaluates the economic impact of pharmaceutical interventions, providing critical insights into cost-effectiveness and efficiency within healthcare systems. In the context of Cyprus, where healthcare expenditures are significant and resources finite, a structured pharmacoeconomic approach can guide decision-making, prioritize interventions, and ensure sustainable healthcare delivery. This paper explores the theoretical foundation of pharmacoeconomics, its relevance in Cyprus’ healthcare landscape, and practical strategies for successful implementation. Key considerations include stakeholder engagement, policy alignment, data availability, and capacity building. By leveraging pharmacoeconomic principles, Cyprus can enhance healthcare efficiency, promote evidence-based decision-making, and ultimately improve health outcomes for its population.
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All articles in the archive are available for download in PDF format. If you encounter any issues or need assistance accessing older volumes, please contact us.
