Collaborative online learning that is integrated into a blended learning model has become a revolutionary concept in nursing education, especially of complex subjects like physiology that are fundamental. In this study, the researcher intends to discuss the design and application of a blended instructional model which integrates both the face-to-face instruction and the structured online group activities into the process of learning in nursing students. The strategy is focused on active learning, group interaction, and knowledge development via discussion forums, virtual group activities, and digital learning tools that correspond with a classroom learning program. The blended model encourages more in-depth conceptual learning in physiological principles by encouraging student interaction and critical thinking and shared problem solving, and supports multiple learner styles as well as learner autonomy. Results indicate that collaborative blended learning does not only enhance academic achievement and understanding of concepts but also enhances communication, professional confidence, and pre-clinical application readiness, which implies its applicability to the modern nursing curriculum.