Welcome to the Asian Journal of Pharmacology Research (AJPR) Current Issues section. Here, you will find the most recent publications that highlight the latest advancements and research in the field of pharmacology. Each issue contains peer-reviewed articles, reviews, case studies, and short communications that contribute to the ongoing dialogue and development within the discipline.
Featured Articles in the Latest Issue
- Volume 3(Issue 1) JANUARY- JUNE 2026
Research Articles
Reengineering Curcumin Bioactivity in Chronic Inflammation Through Nanocarrier-Based Systems
Vol.3(1); Pages:1-9. Published on April 2026
Abstract
Limitation of curcumin in therapeutics such as low bioavailability and poor solubility has been a major limitation to the potential clinical use of curcumin despite its highly effective anti-inflammatory effects. In the present study, the authors examine the construction and analysis of a polymer-based nanocarrier system that would facilitate the delivery and effect of curcumin. The synthesis of the nanoparticles was done through a solvent evaporation technique, and the zeta potential, size, capsulation efficiency, and release kinetics was determined. Anti-inflammatory effects were measured in vitro in lipopolysaccharide-induced macrophage models and in vivo in a rodent model of chronic inflammation. Findings revealed that there was massive cellular uptake and constant release of drugs as opposed to free curcumin. Moreover, the treated groups displayed large declines in pro-inflammatory cytokines as TNF-alpha and IL-6. The histopathological examination revealed lesser tissue injury and inflammatory infiltration. The results indicate that pharmacokinetic obstacles can be avoided by nanocarrier-mediated delivery and that therapeutic outcomes can be improved in this way. This is a promising strategy to enhance clinical utility of curcumin in treatment of chronic inflammatory diseases and should be considered through additional translational research.
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Pharmacokinetic Evaluation of a Novel Oral Antidiabetic Compound in Healthy Volunteers
Vol.3(1); Pages:10-18. Published on May 2026
Abstract
Advancement of new antidiabetic agents must undergo thorough pharmacokinetic profiling to provide the drug with a high level of safety and efficacy. In this study the pharmacokinetic parameters of an orally synthesized antidiabetic compound are assessed in healthy adult volunteers. Single dose, randomized, open-ended design was used with 40 subjects. Blood samples were taken in specific intervals and in a specific analysis with the help of high-performance liquid chromatography. Important pharmacokinetic parameters such as Cmax, Tmax, half-life and area under the curve (AUC) were determined. The compound exhibited high absorption rate with a Tmax of about 2 hours and half-life favouring once-daily dosing. There were no any serious adverse events and the drug was well tolerated among all the participants. There was a dose proportionality which demonstrated predictable pharmacokinetics. Besides, there was improvement in glucose uptake and insulin sensitivity indicative by preliminary pharmacodynamic markers. The outcomes validate additional clinical testing of the compound and give ground on Phase II trials in diabetic groups. This research paper is also added to the increasing body of literature on the issue of innovative oral therapies to manage diabetes.
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Harnessing Gut Microbial Activity to Optimize Drug Biotransformation and Clinical Response
Vol.3(1); Pages:19-27. Published on May 2026
Abstract
Emerging evidence suggests that gut microbiota significantly influences drug metabolism, efficacy, and toxicity. This study explores the relationship between microbiome composition and pharmacokinetic variability in patients undergoing long-term pharmacotherapy. A cohort of 120 patients receiving standard cardiovascular medications was analyzed. Fecal samples were collected for microbiome sequencing, and drug plasma levels were measured to assess metabolic variability. The findings revealed distinct microbial signatures associated with altered drug metabolism rates. Specifically, increased abundance of certain bacterial genera correlated with enhanced enzymatic activity affecting drug biotransformation. Patients with diverse microbiota profiles exhibited more stable drug plasma concentrations and improved therapeutic responses. Conversely, dysbiosis was linked to reduced drug efficacy and increased adverse effects. The study highlights the importance of considering microbiome composition in personalized medicine approaches. Modulating gut microbiota through dietary interventions or probiotics may represent a novel strategy to optimize pharmacotherapy. These findings pave the way for integrating microbiome analysis into routine clinical practice.
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Transdermal Delivery Technologies in Pain Management: System-Level Insights and Optimization
Vol.3(1); Pages:28-37. Published on May 2026
Abstract
Transdermal drug delivery system (TDDS) is another non-invasive method of pain management, which is sustained release of drugs and enhanced compliance by the patient. This paper is a comparison of the effectiveness and permeability of three various TDDS formulations that include a nonsteroidal anti inflammatory drug (NSAID). These formulations were matrix patches, reservoir systems and gels that were microemulsions-based. Franz diffusion cells were used to conduct in vitro permeation studies and in vivo evaluation was done with animal models. It was found that the systems using microemulsions had a higher permeation rate and faster onset of action whereas the matrix patches had more controlled and sustained drug release. The reservoir systems exhibited moderate performance but were related to greater variability. All the formulations were found to be safe according to skin irritation studies with very few adverse reactions. The comparative analysis shows the strengths and weaknesses of each system with emphasis on the possibility of microemulsion-based TDDS in the acute pain cases and matrix systems in chronic cases. The results provide helpful information towards designing and optimization of transdermal therapies.
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Herb–Drug Interaction Dynamics in Antihypertensive Therapy: Pharmacological and Safety Perspectives
Vol.3(1); Pages:38-46. Published on June 2026
Abstract
The combination of herbal supplement and the traditional antihypertensive drugs have brought up issues of interaction with the latter medications and safety of users. The paper examines the level and clinical value of such interactions in hypertensive patients. Cross-sectional analysis was carried out on 150 patients who were under antihypertensive treatment. Structured interviews and review of medical record collected data on usage of herbal supplement, treatment history and clinical outcomes. The findings indicated that about 38 percent of patients were taking herbal products in some form in combination with prescribed drugs. Particularly, it is important to mention that some herbal supplements such as ginseng and garlic were linked to the change in the blood pressure management and the risk of adverse effects. A mechanism that was identified was pharmacokinetic interactions with enzymes in the cytochrome P450 category. The paper highlights the significance of education of healthcare providers and patients on the effects of herbal drugs. There is need to enhance pharmacovigilance systems and regulatory controls so as to reduce the risks and practice safe therapeutic conducts. These results demonstrate that combined methods are needed in the management of polypharmacy.
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