Journal of Research in Pharmaceutics (JRP) proudly presents the latest research and developments in the field of pharmaceutical sciences. Our current issue features a diverse range of articles, including original research, reviews, and case studies, all aimed at advancing knowledge and practice in the field.
Featured Articles in the Latest Issue
- Volume 3(Issue 1)JANUARY- JUNE 2026
Research Articles
Nanostructured Lipid Carriers for Enhanced Oral Bioavailability of Antiviral Agents
Vol.3(1); Pages:1-10. Published on March 2026
Abstract
Nanostructured lipid carriers (NLCs) have become a promising mode of drug delivery to increase the oral bioavailability of a poorly soluble antiviral agent. The objective of this study was to design and develop NLCs to entrap a model antiviral agent and to measure the pharmacokinetic activity of the nanoparticles. High-shear homogenization method was used to prepare the NLCs and characterized based on the particle size, zeta potential, drug encapsulation efficiency and stability. In vitro release assays were able to show a duration of 48 hours with respect to a sustained drug release profile. Also, in vivo pharmacokinetic analysis of rodent models showed a high-enhanced bioavailability relative to standard formulations due to enhanced intestinal absorption and decreased first-pass metabolism. The safety of the developed system was checked by the histopathological analysis. The results indicate that NLCs provide a realistic approach to enhancing the pharmacokinetic efficacy of antiviral agents of low solubility. This study aids in the further development of the nanocarrier-based system of oral drug delivery and contributes to its possible clinical implementation.
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Evaluation of Herbal Alkaloids in Modulating Cytochrome P450 Enzymatic Activity
Vol.3(1); Pages:11-19. Published on April 2026
Abstract
Herbal alkaloids are widely used in traditional medicine, yet their interactions with drug-metabolizing enzymes remain insufficiently understood. This study investigates the modulatory effects of selected herbal alkaloids on cytochrome P450 (CYP450) enzyme activity. Using human liver microsomes, the inhibitory and inductive effects of the compounds were assessed on key CYP isoforms, including CYP3A4 and CYP2D6. Enzyme kinetics were analyzed to determine inhibition constants and potential drug interaction risks. The results revealed that certain alkaloids exhibited strong inhibitory effects, potentially leading to altered metabolism of co administered drugs. Additionally, molecular docking studies provided insights into binding interactions within enzyme active sites. These findings highlight the importance of evaluating herbal-drug interactions in clinical settings. The study underscores the need for regulatory consideration of herbal supplements and their pharmacokinetic implications, contributing valuable data for safer therapeutic practices involving combined herbal and conventional treatments.
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Smart Hydrogel Platforms for Controlled Drug Release in Colonic Environments
Vol.3(1); Pages:20-28. Published on May 2026
Abstract
Targeted drug delivery to the colon is essential for the effective treatment of inflammatory bowel diseases and colorectal cancer. This study focuses on the design and evaluation of pH-responsive hydrogel systems capable of site-specific drug release. Hydrogels were synthesized using cross-linked polymer networks sensitive to pH variations along the gastrointestinal tract. Swelling studies demonstrated minimal expansion in acidic environments and significant swelling at colonic pH levels. Drug loading efficiency and release kinetics were evaluated using a model anti-inflammatory drug. The hydrogels exhibited controlled and targeted drug release, minimizing premature drug leakage in upper gastrointestinal conditions. Mechanical strength and biocompatibility assessments confirmed the suitability of the hydrogels for oral administration. The results indicate that pH-responsive hydrogels represent a promising platform for colon-specific drug delivery, offering improved therapeutic outcomes and reduced systemic side effects. This work advances the development of smart drug delivery systems in pharmaceutics.
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Lipid Vesicle–Based Delivery of Anticancer Agents for Improved Stability and Therapeutic Performance
Vol.3(1); Pages:29-38. Published on May 2026
Abstract
Liposomal drug delivery systems have gained prominence for improving the therapeutic index of anticancer agents. This study explores the formulation and evaluation of liposome-encapsulated chemotherapeutic drugs aimed at enhancing stability and reducing systemic toxicity. Liposomes were prepared using the thin-film hydration method and characterized for size distribution, encapsulation efficiency, and surface charge. Stability studies indicated prolonged shelf life under controlled conditions. In vitro cytotoxicity assays demonstrated enhanced efficacy against cancer cell lines compared to free drug formulations. Additionally, in vivo studies in tumor-bearing models showed improved drug accumulation at tumor sites due to enhanced permeability and retention effects. Reduced cardiotoxicity and systemic side effects were also observed. These findings support the potential of liposomal encapsulation as an effective strategy for cancer therapy. The study contributes to ongoing efforts in optimizing nanocarrier systems for safer and more efficient anticancer treatments.
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Evaluating Safety Trends of Biologic Therapies via Pharmacovigilance Data Exploration
Vol.3(1); Pages:39-48. Published on May 2026
Abstract
Biologic therapies have revolutionized the treatment of chronic and autoimmune diseases; however, their safety profiles require continuous monitoring. This retrospective pharmacovigilance study analyzes reported adverse drug reactions (ADRs) associated with commonly prescribed biologics using international safety databases. Data were systematically collected and categorized based on severity, frequency, and organ system involvement. The analysis revealed that immunological and dermatological reactions were among the most frequently reported ADRs. Signal detection methods identified potential new safety concerns that warrant further investigation. Comparative analysis across different biologic classes provided insights into varying risk profiles. The study emphasizes the importance of robust pharmacovigilance systems in identifying and mitigating risks associated with biologic therapies. The findings contribute to improved clinical decision-making and patient safety by highlighting critical areas for monitoring and regulatory oversight.
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