Incorporation of nutritionally dense crops in staple-based systems provides a route to tackling the food and nutritional security problems of smallholder agro ecosystems. This was a field research that evaluated agronomic and nutritional performance of intercropping maize (Zea mays L.) with moringa ( Moringa oleifera ) under rainfed conditions in Ghana during two growing seasons. The trial was assessing alternate row and paired row intercropping systems to those of monoculture maize. Major performance indicators were land equivalent ratio (LER), grain yield and micronutrient output per unit area. The obtained results indicated that the average LER was 1.41, which indicated that larger land-use efficiency in intercropped plots is more effective. Even though yields of maize improved minimally (6.2 percent), the nutritional content of protein and iron across the system rose significantly (19.7 and 23.5 percent, respectively) because of moringa leaves which contain both nutrients in abundant quantities. This shows a synergistic benefit both with the respect to stability of yields, as well as nutritional quality. The results portray the maize moringa intercropping as a potential tool of nutritional intensification and sustainable land management option in any tropical smallholder farming environment.